In vitro antimicrobial and in vivo antioomycete activities of the novel antibiotic thiobutacin.
نویسندگان
چکیده
BACKGROUND A number of synthetic fungicides are not effective when confronted by oomycete pathogens because many fungicide targets are absent from oomycetes. Moreover, resistance to fungicides has already arisen in oomycete species, and thus development of new, effective and safe compounds for use in oomycete disease control is necessary. RESULTS Zoospore lysis began at 10 microg mL(-1) of thiobutacin, and most of the zoospores were collapsed at 50 microg mL(-1). Thiobutacin also revealed inhibitory activity against the cyst germination and hyphal growth of Phytophthora capsici at 50 microg mL(-1). Treatment with thiobutacin exhibited protective activity against development of Phytophthora disease on pepper plants. CONCLUSION The authors verified in vitro antioomycete activity of thiobutacin against P. capsici and its control efficacy against Phytophthora blight in vivo. This is the first report to demonstrate in vivo antioomycete activity of the novel antibiotic thiobutacin against P. capsici infection.
منابع مشابه
Synthesis, In vitro Antimicrobial and Cytotoxic Activities of Some Novel Bis- 1, 3, 4-oxadiazoles
A series of novel bis-1,3,4-oxadizaoles were synthesized by oxidative cyclisation of respective Schiff bases derived from dicarbohydrazide using ceric ammonium nitrate (CAN) as catalyst. The synthesized compounds were screened for in vitro antibacterial activity against Staphylococcus aureus (MTCC 87), Escherichia coli (MTCC 46) and antifungal activity against Candida albicans (NCIM 3471) by tw...
متن کاملIn vitro study of antibacterial activities of ethanol, methanol and acetone extracts from sea cucumber Holothuria parva
Sea cucumbers are the most important medicinal group among echinoderms. The presence of a wide range of natural bioactive compounds from sea cucumbers has been confirmed in many studies. This study was aimed to evaluate the antibacterial activities of ethanol, methanol and acetone extracts from sea cucumber Holothuria parva. The sea cucumbers were collected during the low tide from Ola village,...
متن کاملIn vitro study of antibacterial activities of ethanol, methanol and acetone extracts from sea cucumber Holothuria parva
Sea cucumbers are the most important medicinal group among echinoderms. The presence of a wide range of natural bioactive compounds from sea cucumbers has been confirmed in many studies. This study was aimed to evaluate the antibacterial activities of ethanol, methanol and acetone extracts from sea cucumber Holothuria parva. Sea cucumber were collected during low tide from Ola village, Bushehr,...
متن کاملSynthesis, Spectral Characterization, In-vitro Antibacterial and Antifungal Activities of Novel (2e)-Ethyl-2-(2-(2, 4-Dinitrophenyl) Hydrazono)-4-(Naphthalen-2-yl)-6-Arylcyclohex-3-Enecarboxylates
In a search for new leads towards potent antimicrobial agents, an array of novel (2E)-ethyl-2-(2-(2,4-dinitrophenyl)hydrazono)-4-(naphthalen-2-yl)-6-arylcyclohex-3-ene carboxylates 17-24 were synthesized and characterized through their melting point, elemental analysis, MS, FT-IR, one-dimensional NMR (1H, D2O exchanged 1H and 13C), two dimensional HOMOCOR and HSQC spectroscopic data. In-vitro m...
متن کاملIn vitro and in vivo study of the antibacterial effects of Nigella sativa methanol extract in dairy cow mastitis
Objective: Nigella Sativa (N. Sativa) seeds were used in traditional medicine for the treatment of a variety of diseases. The seed extracts and oil of this plant have shown various pharmacological properties including antimicrobial actions. In this study, the in vitro and in vivo antibacterial effects of methanol extract of the seeds against pathogenic bacteria causing mastitis in cows have bee...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Pest management science
دوره 64 2 شماره
صفحات -
تاریخ انتشار 2008